UCLA Radiology
UCLA Thoracic Imaging
Publications
UCLA Thoracic Imaging Publication
December 2010

Baseline characteristics of participants in the randomized national lung screening trial.

National Lung Screening Trial Research Team, Aberle DR, Adams AM, Berg CD, Clapp JD, Clingan KL, Gareen IF, Lynch DA, Marcus PM, Pinsky PF.
The National Lung Screening Trial (NLST), a randomized study conducted at 33 US sites, is comparing lung cancer mortality among persons screened with reduced dose helical computerized tomography and among persons screened with chest radiograph. In this article, we present characteristics of the study population.
October 2010

Priorities for Pediatric Prehospital Research

Foltin GL, Dayan P, Tunik M, Marr M, Leonard J, Brown K, Hoyle J Jr, Lerner EB; Prehospital Working Group of the Pediatric Emergency Care Applied Research Network.
Up to 3 million US children are cared for by emergency medical services (EMSs) annually. Limited research exists on pediatric prehospital care. The Pediatric Emergency Care Applied Research Network (PECARN) mission is to perform high-quality research for children, including prehospital research. Our objective was to develop a pediatric-specific prehospital research agenda.
October 2010

National Lung Cancer Screening Trial American College of Radiology Imaging Network Specimen Biorepository Originating from the Contemporary Screening for the Detection of Lung Cancer Trial (NLST, ACRIN 6654): Design, Intent, and Availability of Specimens for Validation of Lung Cancer Biomarkers.

Patz EF Jr, Caporaso NE, Dubinett SM, Massion PP, Hirsch FR, Minna JD, Gatsonis C, Duan F, Adams A, Apgar C, Medina RM, Aberle DR.
September 2010

Chronic Obstructive Pulmonary Disease Phenotypes: the Future of COPD

Han MK, Agusti A, Calverley PM, Celli BR, Criner G, Curtis JL, Fabbri LM, Goldin JG, Jones PW, Macnee W, Make BJ, Rabe KF, Rennard SI, Sciurba FC, Silverman EK, Vestbo J, Washko GR, Wouters EF, Martinez FJ.
Significant heterogeneity of clinical presentation and disease progression exists within chronic obstructive pulmonary disease (COPD). Although FEV1 inadequately describes this heterogeneity, a clear alternative has not emerged. The goal of phenotyping is to identify patient groups with unique prognostic or therapeutic characteristics, but significant variation and confusion surrounds use of the term "phenotype" in COPD. Phenotype classically refers to any observable characteristic of an organism, and up until now, multiple disease characteristics have been termed COPD phenotypes. We, however, propose the following variation on this definition: "a single or combination of disease attributes that describe differences between individuals with COPD as they relate to clinically meaningful outcomes (symptoms, exacerbations, response to therapy, rate of disease progression, or death)."
September 2010

A Randomized Study of Endobronchial Valves for Advanced Emphysema.

Sciurba FC, Ernst A, Herth FJ, Strange C, Criner GJ, Marquette CH, Kovitz KL, Chiacchierini RP, Goldin J, McLennan G.
One of the characteristics of severe emphysema is hyperinflation of regions of the lungs. In this trial, valves that prevented air entry but allowed air to escape were placed in lobar airways. Patients receiving endobronchial valves had modest improvements in lung function and exercise performance.
September 2010

Lung Cancer Staging Essentials: The New TNM Staging System and Potential Imaging Pitfalls.

Uybico SJ, Wu CC, Suh RD, Le NH, Brown K, Krishnam MS.
Lung cancer is the leading cause of cancer-related deaths worldwide, with a dismal 5-year survival rate of 15%. The TNM (tumor-node-metastasis) classification system for lung cancer is a vital guide for determining treatment and prognosis. Despite the importance of accuracy in lung cancer staging, however, correct staging remains a challenging task for many radiologists.
August 2010

25-on-25: Twenty-five Perspectives on Twenty-five Years of Cardiopulmonary Imaging. Part III.

Boiselle PM, Aberle DR, Bankier AA, de Roos A, Gefter WB, Goodman L, Grenier P, Hansell DM, Herold CJ, Im JG, Johkoh T, Kauczor HU, Kazerooni E, Kono M, Levin DC, MacMahon H, McLoud TC, Miller SW, Mller NL, Naidich DP, Prince MR, Rmy-Jardin MR, Schoepf UJ, Stillman AE, Webb WR, White CS.
August 2010

ACR Appropriateness Criteria(R) Hemoptysis.

Jeudy J, Khan AR, Mohammed TL, Amorosa JK, Brown K, Dyer DS, Gurney JW, MacMahon H, Saleh AG, Vydareny KH; Expert Panel on Thoracic Imaging.
Hemoptysis is defined as the expectoration of blood originating from the tracheobronchial tree or pulmonary parenchyma, ranging from 100mL to 1L in volume over a 24-hour period. This article reviews the literature on the indications and usefulness of radiologic studies for the evaluation of hemoptysis.
August 2010

Recurrent Pulmonary Capillary Hemangiomatosis After Bilateral Lung Transplantation.

Lee C, Suh RD, Krishnam MS, Lai CK, Fishbein MC, Wallace WD, Chen A, Saggar R, Saggar R, Belperio JA, Ardehali A, Ross DJ.
Pulmonary capillary hemangiomatosis (PCH) is a rare cause of pulmonary hypertension characterized by uncontrolled capillary proliferation in the pulmonary interstitium and alveolar walls. Lung transplantation remains the only definitive treatment. To date, there have been no reported cases of recurrent PCH after lung transplantation. We present a case that describes important radiologic and clinical features of PCH and raises questions about its pathogenesis.
June 2010

Normalized CT dose index of the CT scanners used in the National Lung Screening Trial.

Cody DD, Kim HJ, Cagnon CH, Larke FJ, McNitt-Gray MM, Kruger RL, Flynn MJ, Seibert JA, Judy PF, Wu X.
Average normalized CT dose index values varied by a factor of almost two for all scanners from all manufacturers. This study was focused on machine-specific normalized CT dose index; patient dose and image quality were not addressed.
April 2010

Thoracic Imaging

Hansell DM, Boiselle PM, Goldin J, Kauczor HU, Lynch DA, Mayo JR, Patz EF Jr.
The various techniques encompassed in the term 'Thoracic Imaging' have had a dramatic effect on the practice of respiratory medicine over the last 25 years. One of many examples is the increased precision with which lung cancer can be preoperatively staged using CT and PET imaging. The increasing sophistication of thoracic imaging tests brings many benefits, but there are caveats. This review considers a selection of techniques and contains state-of-the-art commentaries by distinguished experts on current challenges and likely future developments.
April 2010

Imaging Lung Disease in Systemic Sclerosis

Strollo D, Goldin J.
Interstitial lung disease and pulmonary hypertension (PH) are the most common cardiopulmonary findings in patients with systemic sclerosis (SSc). About two thirds of patients suffering from SSc develop scleroderma interstitial lung disease. PH is present in about 20% of SSc patients and is typically associated with severe lung disease, although it may be an isolated manifestation of SSc. High-resolution CT scanning is a key method for evaluating chest involvement. There are four roles of imaging in scleroderma interstitial lung disease: 1) detection of lung involvement, 2) identification of patients likely to respond to treatment, 3) assessment of treatment efficacy, and 4) exclusion of other significant diseases to include PH and cardiac and esophageal abnormalities.
March - April 2010

Systemic Sclerosis-associated Interstitial Lung Disease-proposed Recommendations for Future Randomized Clinical Trials.

Khanna D, Brown KK, Clements PJ, Elashoff R, Furst DE, Goldin J, Seibold JR, Silver RM, Tashkin DP, Wells AU.
Pulmonary disease is the leading cause of morbidity and mortality in patients with systemic sclerosis (SSc). Recent well-designed trials in SSc-associated interstitial lung disease (SSc-ILD) have provided important insights regarding outcome measures and trial design. Recent investigations into the pathogenesis of SSc-ILD have led to a renewed interest in assessing targeted therapies in SSc-ILD. With this in mind, we propose recommendations for the design of future SSc-ILD studies in this review.
March 2010

Reproducibility of lung and lobar volume measurements using computed tomography.

Brown MS, Kim HJ, Abtin F, Da Costa I, Pais R, Ahmad S, Angel E, Ni C, Kleerup EC, Gjertson DW, McNitt-Gray MF, Goldin JG.
Lung and lobar volume measurements from computed tomographic (CT) imaging are being used in clinical trials to assess new minimally invasive emphysema treatments aiming to reduce lung volumes. Establishing the reproducibility of lung volume measurements is important if they are to be accepted as treatment planning and outcome variables. The aims of this study were to (1) investigate the correlation between lung volumes assessed on CT imaging and on pulmonary function testing (PFT), (2) compare the two methods' reproducibility, and (3) assess the reproducibility of CT lobar volumes.
Feburary 2010

National Institutes of Health State-of-the-Science Conference Statement: Diagnosis and Management of Ductal Carcinoma In Situ September 2224, 2009

Allegra CJ, Aberle DR, Ganschow P, Hahn SM, Lee CN, Millon-Underwood S, Pike MC, Reed SD, Saftlas AF, Scarvalone SA, Schwartz AM, Slomski C, Yothers G, Zon R.
To provide health-care providers, patients, and the general public with a responsible assessment of currently available data on the diagnosis and management of ductal carcinoma in situ (DCIS).

February 2010

25-on-25: twenty-five perspectives on twenty-five years of cardiopulmonary imaging.

Boiselle PM, Aberle DR, Bankier AA, de Roos A, Gefter WB, Goodman L, Grenier P, Hansell DM, Herold CJ, Im JG, Johkoh T, Kauczor HU, Kazerooni E, Kono M, Levin DC, MacMahon H, McLoud TC, Miller SW, Mller NL, Naidich DP, Prince MR, Rmy-Jardin MR, Schoepf UJ, Stillman AE, Webb WR, White CS.